Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656722 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL14036541 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| Diethylamine SCHEMBL5988480 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL5951712 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL12345636 | 0.72 | ALDH1A1 (0.56) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL12797863 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL11513154 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL31123471 | 0.72 | ALDH1A1 (0.70) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| Piperidine SCHEMBL11782163 | 0.71 | MAPK1 (0.41) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 | |
| SCHEMBL1771694 | 0.70 | HTR2C (0.44) | ALDH1A1HSD17B10CYP1A2ALOX15CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644362-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | Sugen, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20060009493-A1 | Indolinone hydrazides as c-Met inhibitors | SUGEN, INC. | 2006-01-12 | — | — | US | disclosed |
| WO-2005005378-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | SUGEN, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009493-A1 | Indolinone hydrazides as c-Met inhibitors | MET, IGF1R, ROS1 | ALDH1A1 143/4885HSD17B10 3197/4885CYP1A2 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.