Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740242 | 1.00 | NFE2L2 (0.52) | NFE2L2TLR9CYP19A1PTGS2MEN1 | |
| SCHEMBL6983829 | 0.85 | TLR9 (0.69) | NFE2L2TLR9CYP19A1PTGS2MEN1 | |
| SCHEMBL2829916 | 0.83 | CYP19A1 (0.49) | TLR9CYP19A1PTGS2MEN1KMT2A | |
| SCHEMBL13988943 | 0.83 | CYP19A1 (0.49) | TLR9CYP19A1PTGS2MEN1KMT2A | |
| SCHEMBL2829919 | 0.83 | CYP19A1 (0.49) | TLR9CYP19A1PTGS2MEN1KMT2A | |
| SCHEMBL2537000 | 0.80 | ERN1 (0.53) | CYP19A1PTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL28585971 | 0.79 | CYP19A1 (0.50) | CYP19A1PTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL10017635 | 0.79 | CYP19A1 (0.50) | CYP19A1PTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL16958259 | 0.79 | CYP19A1 (0.50) | CYP19A1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11212736 | 0.77 | NFE2L2 (0.61) | NFE2L2TLR9CYP19A1PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615949-A1 | PROCESS FOR THE PREPARATION OF MACROCYCLIC COMPOUNDS BY RUTHENIUM COMPLEX CATALYSED METATHESIS REACTION | Boehringer Ingelheim International GmbH (DE) | 2006-01-18 | — | — | EP | disclosed |
| US-20040248779-A1 | Process for the preparation of macrocyclic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| WO-2004089974-A1 | PROCESS FOR THE PREPARATION OF MACROCYCLIC COMPOUNDS BY RUTHENIUM COMPLEX CATALYSED METATHESIS REACTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248779-A1 | Process for the preparation of macrocyclic compounds | CCND2, CYP1B1, PRMT1 | NFE2L2 228/4885TLR9 4442/4885CYP19A1 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.