Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
| ▸ | ME1 | P48163 | 1/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27538189 | 0.70 | SMN1; SMN2 (0.44) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL8908929 | 0.68 | POLB (0.67) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL4861996 | 0.68 | SMN1; SMN2 (0.45) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL4855129 | 0.68 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL26179616 | 0.67 | POLB (0.71) | POLBSMN1; SMN2ME2ME1ME3 | |
| Hydrochloric Acid SCHEMBL21681605 | 0.67 | POLB (0.65) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL3170967 | 0.66 | SMN1; SMN2 (0.70) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL19013642 | 0.65 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2ME2ME1ME3 | |
| SCHEMBL526194 | 0.64 | GAA (0.57) | POLBSMN1; SMN2TDP1KMT2AALDH1A1 | |
| SCHEMBL6618388 | 0.64 | POLB (0.65) | POLBSMN1; SMN2ME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427732-B1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO 1,2-A|PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | PROCTER & GAMBLE (US) | 2006-07-12 | — | — | EP | disclosed |
| EP-1427732-A1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO 1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6566357-B1 | To inhibit the extracellular release of inflammatory cytokines; therapy | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |
| WO-2003024973-A1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |