Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | PPIA | P62937 | 10/20 | 0.53 |
| ▸ | CFD | P00746 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18836470 | 0.87 | LTA4H (0.51) | LTA4HMAPK14PPIACFDSGMS2 | |
| SCHEMBL3946071 | 0.85 | PPIA (0.52) | LTA4HMAPK14PPIASGMS2BRD4 | |
| SCHEMBL7052623 | 0.84 | PPIA (0.53) | LTA4HMAPK14PPIASGMS2 | |
| SCHEMBL18836335 | 0.83 | LTA4H (0.48) | LTA4HMAPK14PPIACFDSGMS2 | |
| SCHEMBL21439550 | 0.82 | PPIA (0.47) | LTA4HMAPK14PPIASGMS2BRD4 | |
| SCHEMBL1178950 | 0.82 | LTA4H (0.60) | LTA4HMAPK14PPIASGMS2ALPG | |
| SCHEMBL28803926 | 0.81 | TBXAS1 (0.54) | LTA4HMAPK14PPIASGMS2PTGER1 | |
| SCHEMBL8809853 | 0.81 | PPIA (0.51) | LTA4HMAPK14PPIASGMS2BRD4 | |
| SCHEMBL18859901 | 0.81 | LTA4H (0.46) | LTA4HMAPK14PPIACFDSGMS2 | |
| SCHEMBL27518122 | 0.81 | KDM4E (0.44) | CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687506-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
| EP-1664047-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | Sanofi-Aventis (FR) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028476-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI-AVENTIS (FR) | 2005-03-31 | — | — | WO | disclosed |