Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369169 | 0.86 | ADORA1 (0.71) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL1895705 | 0.84 | ADORA1 (0.71) | ADORA1ADORA2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5744860 | 0.83 | ADORA1 (0.60) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL15286427 | 0.77 | ADORA1 (0.67) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL15286448 | 0.77 | ADORA1 (0.67) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL18893661 | 0.76 | RXFP1 (0.67) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL8814751 | 0.76 | ABCB1 (0.64) | ADORA2AMAPTSMN1; SMN2NPC1PKM | |
| SCHEMBL15452668 | 0.75 | ALDH1A1 (0.66) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL18893664 | 0.74 | ADORA2A (0.64) | ADORA1ADORA2AADORA2BRXFP1MAPT | |
| SCHEMBL18292559 | 0.74 | ALDH1A1 (0.65) | ADORA1ADORA2AADORA2BRXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |