SCHEMBL5740916

SCHEMBL5740916

CC(C)(C)OC(=O)CN(Cc1cccc(C(F)(F)F)c1)S(=O)(=O)c1ccc(Br)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.54
HTT P42858 2/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
MMP2 P08253 2/20 0.46
MMP9 P14780 2/20 0.46
MMP13 P45452 2/20 0.46
MMP1 P03956 1/20 0.46
MMP8 P22894 1/20 0.46
BMP1 P13497 1/20 0.46
CA12 O43570 4/20 0.44
CA1 P00915 4/20 0.44
CA2 P00918 4/20 0.44
CA4 P22748 4/20 0.44
CA9 Q16790 4/20 0.44
MEP1B Q16820 3/20 0.44
NPSR1 Q6W5P4 2/20 0.44
NR1D1 P20393 1/20 0.43
TP53 P04637 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4466382 0.75 MAPT (0.46) MAPTHTTKMT2AMEN1MMP2
SCHEMBL2194247 0.75 SMN1; SMN2 (0.49) HTTMMP2MMP9MMP13MMP1
SCHEMBL21315101 0.73 NR1D1 (0.56) MAPTKMT2AMEN1MMP2MMP9
SCHEMBL4467883 0.72 CA12 (0.50) MAPTHTTMMP2MMP9MMP13
SCHEMBL120825 0.72 HPGD (0.61) HTTKMT2AMEN1
SCHEMBL2243742 0.71 DAGLA (0.65) MAPTHTTKMT2AMEN1TP53
SCHEMBL13171948 0.70 TP53 (0.58) MAPTHTTKMT2AMEN1MMP2
SCHEMBL22208229 0.70 NR1D1 (0.58) MAPTKMT2AMMP2MMP9MMP13
SCHEMBL28191746 0.69 FFAR4 (0.52) MAPTHTTKMT2AMEN1
SCHEMBL2239998 0.69 DAGLA (0.64) MMP2MMP9MMP13MMP1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1812978-A Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b INST PHARMACEUTICAL DISCOVERY (US) 2006-08-02 CN disclosed
EP-1620422-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP disclosed
WO-2004099170-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed