Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 6/20 | 0.48 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP14 | P50281 | 3/20 | 0.48 |
| ▸ | MMP16 | P51512 | 2/20 | 0.48 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133773 | 0.88 | LMNA (0.59) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL1133821 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL2195059 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL1133895 | 0.81 | MMP2 (0.69) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL2197073 | 0.79 | NR1D1 (0.48) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL1134049 | 0.77 | ALDH1A1 (0.41) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL7452484 | 0.75 | KEAP1 (0.47) | MMP13MMP1MMP8NR1D1ALDH1A1 | |
| SCHEMBL5740916 | 0.75 | MAPT (0.54) | SMN1; SMN2HTTMMP13MMP1MMP8 | |
| SCHEMBL1134063 | 0.74 | MMP8 (0.83) | MMP13MMP1MMP8MMP9MMP2 | |
| SCHEMBL7243688 | 0.73 | MMP1 (0.46) | SMN1; SMN2MMP13MMP1MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524194-B2 | Radiolabelled MMP selective compounds | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2013-09-03 | — | — | US | disclosed |
| US-20110171133-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171133-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | MMP1, MMP3, MMP9 | SMN1; SMN2 4273/4885LMNA 1567/4885HTT 3092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.