Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891125 | 0.82 | MAPK1 (0.37) | PKMTACR1MAPK1GRM5FLT3 | |
| SCHEMBL2897646 | 0.82 | TACR1 (0.37) | PKMTACR1MAPK1GRM5FLT3 | |
| SCHEMBL2897581 | 0.79 | MAPK1 (0.40) | TACR1MAPK1GRM5FLT3GSK3B | |
| SCHEMBL2893681 | 0.79 | GRM5 (0.56) | PKMMAPK1GRM5FLT3GSK3B | |
| SCHEMBL2897403 | 0.75 | GRM5 (0.38) | TACR1MAPK1GRM5FLT3GSK3B | |
| SCHEMBL2895705 | 0.75 | CYP3A4 (0.52) | TACR1MAPK1FLT3GSK3BALPL | |
| SCHEMBL5757429 | 0.71 | MAPK1 (0.33) | MAPK1GRM5ALPLALPI | |
| SCHEMBL5757422 | 0.71 | MAPK1 (0.33) | MAPK1GRM5ALPLALPI | |
| SCHEMBL5754386 | 0.71 | MAPK1 (0.41) | TACR1MAPK1GRM5ALPLALPI | |
| SCHEMBL2893692 | 0.69 | ALPL (0.41) | GRM5ALPLALPIGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | claimed |