Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | RGS12 | O14924 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897581 | 0.86 | MAPK1 (0.40) | MAPK1ALPLALPIGRM5RXFP1 | |
| SCHEMBL2889444 | 0.82 | GRM5 (0.45) | MAPK1NOS1NOS2GRM5KDM4E | |
| SCHEMBL2889474 | 0.82 | GRM5 (0.45) | MAPK1NOS1NOS2GRM5KDM4E | |
| SCHEMBL2889476 | 0.82 | GRM5 (0.45) | MAPK1NOS1NOS2GRM5KDM4E | |
| SCHEMBL2893692 | 0.79 | ALPL (0.41) | ALPLALPIGRM5RXFP1KDM4E | |
| SCHEMBL2895698 | 0.75 | CHRNB2 (0.41) | ALPLALPIGRM5RXFP1TDP1 | |
| SCHEMBL5753191 | 0.74 | CYP3A4 (0.43) | ALPLALPIGRM5RXFP1TDP1 | |
| SCHEMBL2898035 | 0.73 | CYP3A4 (0.37) | ALPLALPIRXFP1TDP1GAA | |
| SCHEMBL5479679 | 0.73 | MAPK1 (0.40) | MAPK1ALPLALPIRXFP1TDP1 | |
| SCHEMBL2893681 | 0.72 | GRM5 (0.56) | MAPK1GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |