Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743423 | 0.94 | MAPT (0.48) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5743044 | 0.91 | AGPAT2 (0.50) | ABCG2MAPTTP53AGPAT2ROCK1 | |
| SCHEMBL5741286 | 0.90 | MAPT (0.53) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5740131 | 0.89 | AGPAT2 (0.54) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5743192 | 0.88 | AGPAT2 (0.57) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5741066 | 0.87 | ACP1 (0.51) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5741832 | 0.87 | AGPAT2 (0.46) | ABCG2MAPTKMT2AHPGDTP53 | |
| SCHEMBL5741806 | 0.87 | BACE1 (0.47) | ABCG2MAPTKMT2AHPGDHTT | |
| SCHEMBL5741974 | 0.85 | AGPAT2 (0.53) | ABCG2MAPTAGPAT2ROCK1ADORA2A | |
| SCHEMBL5743344 | 0.85 | AGPAT2 (0.53) | ABCG2MAPTAGPAT2ROCK1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |