Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208538 | 0.81 | PDE4A (0.51) | SMN1; SMN2KIF11ENPP2PDE4APDE4B | |
| SCHEMBL5246052 | 0.80 | TLR7 (0.43) | SMN1; SMN2KIF11ENPP2PDE4APDE4B | |
| SCHEMBL5246246 | 0.79 | PDE4A (0.49) | SMN1; SMN2KIF11PDE4APDE4BPDE4C | |
| SCHEMBL5741127 | 0.79 | KIF11 (0.48) | SMN1; SMN2KIF11PDE4APDE4BPDE4C | |
| SCHEMBL3871568 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2KIF11PDE4APDE4BPDE4C | |
| SCHEMBL5899045 | 0.77 | KIF11 (0.51) | SMN1; SMN2KIF11POLBMEN1GAA | |
| SCHEMBL5739696 | 0.77 | KIF11 (0.55) | SMN1; SMN2KIF11PDE4APDE4BPDE4C | |
| SCHEMBL4042840 | 0.74 | KIF11 (0.53) | SMN1; SMN2KIF11TSHRMEN1GAA | |
| SCHEMBL3905973 | 0.73 | KIF11 (0.51) | KIF11 | |
| SCHEMBL3901729 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2KIF11PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |