Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871568 | 0.89 | SMN1; SMN2 (0.53) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6208538 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6208219 | 0.83 | SMN1; SMN2 (0.45) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3901729 | 0.82 | SMN1; SMN2 (0.48) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5741124 | 0.79 | SMN1; SMN2 (0.42) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5741127 | 0.79 | KIF11 (0.48) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6208130 | 0.78 | KIF11 (0.48) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5742407 | 0.78 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKIF11 | |
| SCHEMBL5246052 | 0.77 | TLR7 (0.43) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3961772 | 0.76 | KIF11 (0.67) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781674-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTION OF CANCER | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018628-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTI ON OF CANCER | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |