Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.51 |
| ▸ | TERT | O14746 | 2/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | FPR1 | P21462 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742707 | 0.92 | AGPAT2 (0.49) | MAPT | |
| SCHEMBL5744066 | 0.91 | DOT1L (0.49) | DOT1LTERTOPRL1OPRM1OPRK1 | |
| SCHEMBL5740861 | 0.90 | MAPT (0.48) | OPRL1MAPT | |
| SCHEMBL5743563 | 0.88 | AGPAT2 (0.56) | OPRL1MAPT | |
| SCHEMBL5742913 | 0.88 | KMT2A (0.43) | MAPT | |
| SCHEMBL5742375 | 0.84 | MAPT (0.51) | MAPT | |
| SCHEMBL5743131 | 0.84 | BACE1 (0.50) | MAPT | |
| SCHEMBL5742115 | 0.83 | DHODH (0.40) | MAPT | |
| SCHEMBL5740573 | 0.82 | DOT1L (0.57) | DOT1LTERTOPRL1OPRM1OPRK1 | |
| SCHEMBL5743033 | 0.82 | MCHR1 (0.47) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |