Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.56 |
| ▸ | TERT | O14746 | 3/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | FPR1 | P21462 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741129 | 0.82 | DOT1L (0.51) | DOT1LOPRL1TERTOPRM1MAPT | |
| SCHEMBL5743245 | 0.81 | AGPAT2 (0.45) | OPRL1MAPT | |
| SCHEMBL5744066 | 0.81 | DOT1L (0.49) | DOT1LOPRL1TERTOPRM1MAPT | |
| SCHEMBL5742553 | 0.81 | DOT1L (0.78) | DOT1LTERTMAPT | |
| SCHEMBL5740488 | 0.74 | HSP90AA1 (0.57) | DOT1LOPRL1TERT | |
| SCHEMBL27890181 | 0.74 | TERT (0.69) | DOT1LOPRL1TERT | |
| SCHEMBL5741412 | 0.74 | DOT1L (0.57) | DOT1LOPRL1TERT | |
| SCHEMBL5744090 | 0.73 | DOT1L (0.59) | DOT1LOPRL1TERTMAPT | |
| SCHEMBL5741763 | 0.73 | DOT1L (0.62) | DOT1LTERTMAPT | |
| SCHEMBL5742707 | 0.73 | AGPAT2 (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |