Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 10/20 | 0.34 |
| ▸ | CTSD | P07339 | 6/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.31 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741883 | 0.88 | PIK3CG (0.38) | LIMK1BACE1PRKCIBACE2 | |
| SCHEMBL5738937 | 0.88 | LIMK1 (0.40) | LIMK1BACE1GABRA1GABRG2GABRB3 | |
| SCHEMBL5740852 | 0.84 | CYP11B2 (0.40) | LIMK1PRKCIRORC | |
| SCHEMBL5738998 | 0.84 | LIMK1 (0.34) | LIMK1RORC | |
| SCHEMBL6502371 | 0.84 | PRMT5 (0.38) | LIMK1PRKCISLC34A2 | |
| SCHEMBL5738867 | 0.83 | ABL1 (0.40) | — | |
| SCHEMBL5741185 | 0.83 | PIK3CG (0.42) | LIMK1KCNH2OTUD7B | |
| SCHEMBL5739106 | 0.82 | CYP11B2 (0.43) | — | |
| SCHEMBL5740728 | 0.80 | ABL1 (0.41) | LIMK1PRKCI | |
| SCHEMBL5738790 | 0.80 | LIMK1 (0.38) | LIMK1SLC34A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406891-B1 | THIOCHROMENONES USED TO COMBAT PAINFUL CONDITIONS AND NEURODEGENERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2006-03-22 | — | — | EP | disclosed |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | LIMK1 4255/4885BACE1 295/4885CTSD 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.