Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111260 | 0.92 | IKBKB (0.49) | PIM1KDRIKBKBMAPTALDH1A1 | |
| SCHEMBL5732572 | 0.90 | CDK8 (0.51) | PIM1KDRIKBKBMAPTALDH1A1 | |
| SCHEMBL5740848 | 0.90 | MAPT (0.47) | PIM1IKBKBMAPTALDH1A1MEN1 | |
| SCHEMBL5743134 | 0.88 | ADORA3 (0.41) | PIM1KDRIKBKBMAPTMEN1 | |
| SCHEMBL5739831 | 0.88 | HSP90AB1 (0.45) | IKBKBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5742012 | 0.87 | MEN1 (0.54) | PIM1KDRIKBKBMAPTALDH1A1 | |
| SCHEMBL6110379 | 0.86 | LIMK1 (0.38) | PIM1KDRIKBKBMAPTALDH1A1 | |
| SCHEMBL6111313 | 0.84 | LIMK1 (0.52) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6110362 | 0.83 | PIM1 (0.44) | PIM1KDRIKBKBMAPTALDH1A1 | |
| SCHEMBL5732791 | 0.82 | FOXM1 (0.51) | PIM1KDRIKBKBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | claimed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | disclosed |