Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730706 | 0.91 | MEN1 (0.52) | MEN1KMT2AIKBKBKDM4EALDH1A1 | |
| SCHEMBL5739770 | 0.91 | MEN1 (0.52) | MEN1KMT2APIM1KDRIKBKB | |
| SCHEMBL5739582 | 0.91 | MEN1 (0.52) | MEN1KMT2APIM1KDRIKBKB | |
| SCHEMBL5729872 | 0.90 | MEN1 (0.67) | MEN1KMT2AIKBKBKDM4EALDH1A1 | |
| SCHEMBL5731048 | 0.90 | LIMK1 (0.56) | MEN1KMT2APIM1KDRKDM4E | |
| SCHEMBL5740127 | 0.89 | MEN1 (0.50) | MEN1KMT2APIM1KDRIKBKB | |
| SCHEMBL5740675 | 0.89 | MEN1 (0.56) | MEN1KMT2APIM1KDRIKBKB | |
| SCHEMBL2851062 | 0.88 | PIM1 (0.55) | MEN1KMT2APIM1KDRKDM4E | |
| SCHEMBL6111088 | 0.88 | MEN1 (0.49) | MEN1KMT2AIKBKBALDH1A1HPGD | |
| SCHEMBL5741487 | 0.87 | PIM1 (0.45) | MEN1KMT2APIM1KDRIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | claimed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | disclosed |