Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858611 | 0.86 | MAPT (0.65) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL1042856 | 0.86 | ALDH1A1 (0.59) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL8956556 | 0.84 | GAA (0.48) | MAPTGAAALDH1A1JAK1ATM | |
| SCHEMBL147437 | 0.82 | ALDH1A1 (0.52) | PBRM1ALDH1A1JAK1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL8993445 | 0.80 | ALDH1A1 (0.50) | PBRM1ALDH1A1JAK1TSHRHSD17B10 | |
| SCHEMBL4849227 | 0.79 | MAPT (0.48) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL28135536 | 0.79 | ALDH1A1 (0.62) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL11869293 | 0.78 | MAPT (0.57) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL10937897 | 0.78 | MAPT (0.74) | MAPTGAAPBRM1ALDH1A1ATM | |
| SCHEMBL533764 | 0.78 | ALDH1A1 (0.50) | MAPTGAAALDH1A1ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707830-A | Method for preparing tetraethyl mikrolon | 天津久日新材料股份有限公司 | 2021-04-27 | — | — | CN | disclosed |
| EP-1157006-B1 | PHENYL- AND PYRIDINYL DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-10-25 | — | — | EP | disclosed |
| CN-1131212-C | Phenyl-and pyridinyl derivatives | HOFFMANN LA ROCHE (CH) | 2003-12-17 | — | — | CN | disclosed |
| US-6596773-B2 | Central nervous system disorders | HOFFMANN-LA ROCHE INC. | 2003-07-22 | — | — | US | disclosed |
| US-20020111367-A1 | Phenyl substituted pyridine and benzene derivatives | BOS MICHAEL (CA) | 2002-08-15 | — | — | US | disclosed |
| US-6407111-B1 | SUBSTANCE P OR NEUROKININ 1 ANTAGONISTS; ANTIINFLAMMATORY, ANTIDEPRESSANT, ANTIARTHRITIC, AND ANTIASTHMATIC AGENTS; PARKINSON*S DISEASE, INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM AND RHEUMATIC DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |
| CN-1085667-C | Substituted tetracyclic azepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2002-05-29 | — | — | CN | disclosed |
| CN-1341101-A | Phenyl-and pyridinyl derivatives | HOFFMANN LA ROCHE (CH) | 2002-03-20 | — | — | CN | disclosed |
| EP-1157006-A2 | PHENYL- AND PYRIDINYL DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-28 | — | — | EP | disclosed |
| EP-0789701-B1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-02-07 | — | — | EP | disclosed |
| US-5552399-A | TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| US-5532374-A | Method of preparation of bis-quinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| WO-1996014320-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-17 | — | — | WO | disclosed |
| EP-0076017-B1 | PHENYL SUBSTITUTED PYRIDO(1,4)BENZODIAZEPINES AND INTERMEDIATES THEREFOR | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-16 | — | — | EP | disclosed |
| EP-0326526-A1 | Aminoketones of substituted dibenzo- and pyridobenzo-azepinones and pharmaceutical compositions | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |
| US-4668675-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-05-26 | — | — | US | disclosed |
| US-4556667-A | (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-03 | — | — | US | disclosed |
| US-4495183-A | ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-01-22 | — | — | US | disclosed |
| US-4447361-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0076017-A2 | Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor | A.H. ROBINS COMPANY, INCORPORATED (US) | 1983-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111367-A1 | Phenyl substituted pyridine and benzene derivatives | BDKRB1, BAK1, PBK | MAPT 4521/4885GAA 2255/4885PBRM1 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.