Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | FASN | P49327 | 3/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741564 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5745251 | 0.87 | AVPR1A (0.46) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5742551 | 0.87 | HPGD (0.46) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5741758 | 0.82 | CA12 (0.47) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5741756 | 0.82 | CA12 (0.47) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL4942034 | 0.82 | OXTR (0.58) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL4942028 | 0.82 | OXTR (0.58) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5481224 | 0.81 | HPGD (0.46) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL8159195 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDMEN1KMT2ATSHR | |
| SCHEMBL5742550 | 0.78 | MKNK1 (0.46) | ALDH1A1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | claimed |