Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062555 | 0.85 | SLC6A2 (0.56) | SLC6A2POLBARHTR4HTT | |
| SCHEMBL12139324 | 0.78 | SLC6A2 (0.50) | SLC6A2POLBHTR4 | |
| SCHEMBL27836296 | 0.76 | POLB (0.53) | SLC6A2POLBHTT | |
| SCHEMBL13322673 | 0.76 | POLB (0.46) | SLC6A2POLBARHTR4HTT | |
| SCHEMBL6909093 | 0.73 | SLC6A2 (0.55) | SLC6A2POLBSLC6A4 | |
| SCHEMBL24031446 | 0.72 | GRM4 (0.53) | SLC6A2POLBHTT | |
| SCHEMBL12140924 | 0.72 | SLC6A2 (0.43) | SLC6A2POLBARHTR4SLC6A4 | |
| SCHEMBL2963786 | 0.72 | HTR4 (0.53) | SLC6A2POLBHTR4 | |
| SCHEMBL6584714 | 0.72 | HTR4 (0.54) | SLC6A2POLBHTR4 | |
| SCHEMBL5801271 | 0.71 | HTR4 (0.52) | SLC6A2POLBHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732887-A1 | 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005097744-A1 | 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2005-10-20 | — | — | WO | disclosed |