Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047004 | 0.84 | MAPK14 (0.61) | MAPK14KDR | |
| SCHEMBL5738800 | 0.84 | KDR (0.48) | MAPK14KDR | |
| SCHEMBL5730197 | 0.84 | KDR (0.56) | MAPK14KDR | |
| SCHEMBL5740240 | 0.81 | KDR (0.53) | MAPK14KDR | |
| SCHEMBL5740841 | 0.78 | MEN1 (0.43) | MAPK14KDR | |
| SCHEMBL5739102 | 0.77 | KDR (0.51) | KDR | |
| SCHEMBL5738412 | 0.77 | MAPK14 (0.51) | MAPK14KDR | |
| SCHEMBL5739048 | 0.77 | MAP2K1 (0.66) | KDR | |
| SCHEMBL5741065 | 0.76 | KDR (0.50) | MAPK14KDR | |
| SCHEMBL5740244 | 0.76 | KDR (0.54) | MAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |