Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.48 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740529 | 0.89 | MCHR1 (0.53) | MCHR1AGPAT2ROCK2TRPV1ACP1 | |
| SCHEMBL5740185 | 0.88 | AGPAT2 (0.53) | MCHR1AGPAT2DHODHDOT1L | |
| SCHEMBL5743489 | 0.86 | AGPAT2 (0.41) | MCHR1AGPAT2DHODHROCK2 | |
| SCHEMBL5740460 | 0.85 | MCHR1 (0.50) | MCHR1AGPAT2ROCK2TRPV1ACP1 | |
| SCHEMBL5739888 | 0.84 | AGPAT2 (0.48) | MCHR1AGPAT2DHODHACP1 | |
| SCHEMBL5741991 | 0.84 | AGPAT2 (0.57) | MCHR1AGPAT2ROCK2TRPV1ACP1 | |
| SCHEMBL5742875 | 0.84 | AGPAT2 (0.57) | MCHR1AGPAT2ROCK2TRPV1ACP1 | |
| SCHEMBL5740835 | 0.83 | AGPAT2 (0.45) | MCHR1AGPAT2DHODH | |
| SCHEMBL5742057 | 0.83 | MCHR1 (0.42) | MCHR1AGPAT2DHODHTRPV1DOT1L | |
| SCHEMBL5742700 | 0.82 | MCHR1 (0.52) | MCHR1AGPAT2ROCK2TRPV1ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |