Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 10/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PLEC | Q15149 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573193 | 0.87 | CA2 (0.64) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL573694 | 0.84 | PKM (0.44) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL15367494 | 0.78 | CISD1 (0.42) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL9042101 | 0.78 | CA1 (0.56) | CA2ALDH1A1LMNATSHRCISD1 | |
| SCHEMBL16645764 | 0.76 | CA1 (0.53) | CA2ALDH1A1HPGDLMNAHIF1A | |
| SCHEMBL7824144 | 0.76 | KDM4E (0.48) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL16581064 | 0.76 | CISD1 (0.56) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL10224099 | 0.76 | KDM4E (0.80) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL574542 | 0.75 | KMT2A (0.46) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL7824071 | 0.74 | SMN1; SMN2 (0.52) | CA2KDM4EALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |