Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 5/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | PIM1 | P11309 | 1/20 | 0.69 |
| ▸ | PRKACA | P17612 | 1/20 | 0.69 |
| ▸ | LTK | P29376 | 1/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.69 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.69 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.69 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.69 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569008 | 0.85 | ABCG2 (0.72) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL13152622 | 0.82 | RAB9A (0.65) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL29941271 | 0.82 | EGFR (1.00) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL8920 | 0.82 | EGFR (1.00) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL8808235 | 0.81 | EGFR (0.90) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL20856873 | 0.80 | EGFR (0.96) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL29394578 | 0.80 | EGFR (0.96) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL5741563 | 0.80 | TRPV1 (0.56) | EGFRERBB2KDRKMT2AFYN | |
| SCHEMBL5569376 | 0.80 | EGFR (0.81) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL5569016 | 0.80 | EGFR (0.75) | ABCG2EGFRERBB2AURKBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060194805-A1 | Capsaicin receptor agonists | NEUROGEN CORPORATION (US) | 2006-08-31 | — | — | US | claimed |
| EP-1678149-A2 | 4-AMINO(AZA)QUINOLINE DERIVATIVES AS CAPSAICIN RECEPTOR AGONISTS | NEUROGEN CORPORATION (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005042498-A2 | 4-AMINO (AZA) QUINOLINE DERIVATIVES AS CAPSAICIN RECEPTOR AGONISTS | NEUROGEN CORPORATION (US) | 2005-05-12 | — | — | WO | claimed |
| US-20060194805-A1 | Capsaicin receptor agonists | NEUROGEN CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194805-A1 | Capsaicin receptor agonists | TRPV1, HCAR1, CNR1 | ABCG2 533/4885EGFR 3398/4885ERBB2 2965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.