Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742833 | 0.90 | MCHR1 (0.48) | MCHR1TERTHRH2HRH3DOT1L | |
| SCHEMBL5742169 | 0.88 | MCHR1 (0.44) | MCHR1TERTDOT1LTLR8LMNA | |
| SCHEMBL5740235 | 0.84 | MCHR1 (0.44) | MCHR1TERTDOT1LTLR8PDPK1 | |
| SCHEMBL5741907 | 0.82 | MCHR1 (0.44) | MCHR1TERTDOT1LTLR8PDPK1 | |
| SCHEMBL5743256 | 0.82 | MCHR1 (0.59) | MCHR1TLR8AGPAT2 | |
| SCHEMBL5740176 | 0.81 | AGPAT2 (0.56) | MCHR1TERTDOT1LPDPK1LMNA | |
| SCHEMBL5742672 | 0.80 | AGPAT2 (0.46) | TERTDOT1LPDPK1LMNATP53 | |
| SCHEMBL5740139 | 0.80 | AGPAT2 (0.60) | DOT1LTP53MAPTAGPAT2 | |
| SCHEMBL5743457 | 0.79 | ACP1 (0.54) | DOT1LTP53MAPTAGPAT2ACP1 | |
| SCHEMBL5743755 | 0.79 | KDM4E (0.55) | MCHR1TERTDOT1LLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |