Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.48 |
| ▸ | AGPAT2 | O15120 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742344 | 0.90 | MCHR1 (0.44) | MCHR1AGPAT2TERTHRH2HRH3 | |
| SCHEMBL5740235 | 0.90 | MCHR1 (0.44) | MCHR1AGPAT2TERTDOT1LTLR8 | |
| SCHEMBL5742308 | 0.88 | AGPAT2 (0.53) | MCHR1AGPAT2ASIC3TLR8 | |
| SCHEMBL5743256 | 0.80 | MCHR1 (0.59) | MCHR1AGPAT2TLR8 | |
| SCHEMBL5740139 | 0.80 | AGPAT2 (0.60) | AGPAT2NPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5743347 | 0.79 | AGPAT2 (0.57) | AGPAT2NPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5742678 | 0.79 | AGPAT2 (0.61) | AGPAT2NPC1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5742169 | 0.78 | MCHR1 (0.44) | MCHR1AGPAT2TERTDOT1LTP53 | |
| SCHEMBL5744288 | 0.78 | KDM4E (0.56) | MCHR1AGPAT2NPC1CYP1A2CYP3A4 | |
| SCHEMBL5742888 | 0.78 | AGPAT2 (0.64) | AGPAT2NPC1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |