Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741966 | 0.88 | LMNA (0.47) | ALDH1A1KDM4ELMNAGAAKMT2A | |
| SCHEMBL5741173 | 0.87 | POLB (0.46) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL5742717 | 0.87 | LMNA (0.46) | ALDH1A1KDM4ELMNAGAAKMT2A | |
| SCHEMBL5742813 | 0.84 | CCR6 (0.46) | ALDH1A1LMNAGAAKMT2APOLB | |
| SCHEMBL5741821 | 0.82 | KDM4E (0.56) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL3823693 | 0.81 | CFTR (0.46) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL5740010 | 0.79 | MEN1 (0.47) | MAPTALDH1A1LMNAGAAKMT2A | |
| SCHEMBL15457181 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAGAAPOLB | |
| SCHEMBL5741867 | 0.77 | LMNA (0.51) | ALDH1A1LMNAGAAPOLBSMN1; SMN2 | |
| SCHEMBL5741940 | 0.77 | LMNA (0.50) | ALDH1A1KDM4ELMNAGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646615-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2004111014-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-12-23 | — | — | WO | disclosed |