Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | WDR5 | P61964 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854050 | 0.92 | ALDH1A1 (0.71) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL30198175 | 0.92 | ALDH1A1 (0.71) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL29493728 | 0.89 | ALDH1A1 (0.69) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL522009 | 0.89 | ALDH1A1 (0.69) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| Hydrochloric Acid SCHEMBL30255520 | 0.88 | ALDH1A1 (0.68) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| Hydrochloric Acid SCHEMBL4003615 | 0.88 | ALDH1A1 (0.68) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL861991 | 0.87 | ALDH1A1 (0.64) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL14464189 | 0.85 | ALDH1A1 (0.79) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL6499951 | 0.84 | ALDH1A1 (0.63) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| Hydrochloric Acid SCHEMBL3201233 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAKMT2AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |