Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.63 |
| ▸ | PPARA | Q07869 | 20/20 | 0.63 |
| ▸ | PPARD | Q03181 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623121 | 0.99 | PPARG (0.64) | PPARGPPARAPPARD | |
| SCHEMBL7538422 | 0.94 | PPARG (0.62) | PPARGPPARAPPARD | |
| SCHEMBL5974090 | 0.94 | PPARG (0.63) | PPARGPPARAPPARD | |
| SCHEMBL7621884 | 0.90 | PPARG (0.52) | PPARGPPARAPPARD | |
| SCHEMBL7727703 | 0.89 | PPARG (0.59) | PPARGPPARAPPARD | |
| SCHEMBL6021601 | 0.88 | PPARG (0.61) | PPARGPPARAPPARD | |
| SCHEMBL7722485 | 0.86 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL5742131 | 0.86 | PPARG (0.63) | PPARGPPARAPPARD | |
| SCHEMBL7727745 | 0.86 | PPARG (0.51) | PPARGPPARAPPARD | |
| SCHEMBL7722506 | 0.86 | PPARG (0.51) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1078923-B1 | Process for the preparation of benzothiophene derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-08 | — | — | EP | disclosed |
| US-6482958-B2 | REACTING A THIOPHENE CARBALDEHYDE COMPOUND WITH VINYLMAGNESIUM HALIDE REAGENT FOLLOWED BY REACTING WITH ACID | HOFFMANN-LA ROCHE INC. | 2002-11-19 | — | — | US | disclosed |
| US-6437144-B2 | CYCLOCARBONYLATION | HOFFMANN-LA ROCHE INC. | 2002-08-20 | — | — | US | disclosed |
| US-20020077488-A1 | Methods for the preparation of 4-hydroxy benzothiophene | JUNGHANS BERND (DE) | 2002-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077488-A1 | Methods for the preparation of 4-hydroxy benzothiophene | SLC5A2, SLC5A1, TST | PPARG 252/4885PPARA 375/4885PPARD 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.