Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058003 | 0.85 | ABCB1 (0.47) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4452291 | 0.80 | BACE1 (0.62) | BACE1KMT2AMEN1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4603331 | 0.79 | BACE1 (0.60) | BACE1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL16057164 | 0.77 | FFAR1 (0.44) | KMT2AMEN1NPC1RAB9AFFAR1 | |
| SCHEMBL13962883 | 0.77 | BACE1 (0.62) | BACE1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL16057405 | 0.77 | PTGER1 (0.46) | KMT2AMEN1SMN1; SMN2NPC1GAA | |
| SCHEMBL16056930 | 0.77 | BID (0.44) | KMT2AMEN1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL16058002 | 0.76 | ABCB1 (0.47) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13962869 | 0.76 | BACE1 (0.60) | BACE1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL4558113 | 0.76 | BACE1 (0.64) | BACE1KMT2AMEN1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442035-B1 | PROCESS FOR THE PREPARATION OF 4- (8-CHLORO-5, 6-DIHYDRO-11H-BENZO-[5,6]-CYCLOHEPTA-[1,2-B]-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZAMBON SPA (IT) | 2006-01-11 | — | — | EP | claimed |