Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
| ▸ | SCD | O00767 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25956596 | 0.92 | IRAK4 (0.83) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL5743892 | 0.90 | RAB9A (0.74) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL17488032 | 0.88 | RAB9A (0.67) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL16562030 | 0.85 | NPC1 (1.00) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL3597174 | 0.84 | IRAK4 (1.00) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL24373774 | 0.83 | IRAK4 (0.84) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL25956581 | 0.83 | IRAK4 (0.84) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL25956583 | 0.83 | IRAK4 (0.84) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL27631617 | 0.82 | IRAK4 (0.54) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL29500516 | 0.82 | LMNA (0.57) | SMN1; SMN2NPC1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1674466-A1 | 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors | 4SC AG (DE) | 2006-06-28 | — | — | EP | disclosed |
| US-4011236-A | N-(BENZIMIDAZOL-2-YL)ARYLCARBOXAMIDES AS ULTRAVIOLET (UV) LIGHT ABSORBERS | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |