Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756156 | 0.81 | HMGCR (0.61) | ALDH1A1HPGDHMGCRSMN1; SMN2TP53 | |
| SCHEMBL5745018 | 0.80 | HMGCR (0.52) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5742188 | 0.80 | HMGCR (0.51) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5742192 | 0.80 | HMGCR (0.51) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5759558 | 0.79 | HMGCR (0.45) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5742189 | 0.78 | CYP2C9 (0.49) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5740858 | 0.78 | HMGCR (0.44) | ALDH1A1HMGCRSMN1; SMN2 | |
| SCHEMBL5761542 | 0.74 | HMGCR (0.54) | ALDH1A1HPGDHMGCRSMN1; SMN2 | |
| SCHEMBL5741333 | 0.74 | HMGCR (0.35) | ALDH1A1HPGDHMGCRSMN1; SMN2TP53 | |
| SCHEMBL20833871 | 0.69 | HPGD (0.55) | ALDH1A1HPGDSMN1; SMN2APOBEC3AHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727541-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | Warner-Lambert Company LLC (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005079790-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-09-01 | — | — | WO | disclosed |