Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.39 |
| ▸ | CTSS | P25774 | 9/20 | 0.39 |
| ▸ | CTSL | P07711 | 8/20 | 0.39 |
| ▸ | CTSB | P07858 | 4/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155759 | 0.87 | CTSK (0.47) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2155832 | 0.87 | CTSL (0.46) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2156811 | 0.84 | CTSK (0.56) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2156417 | 0.82 | CTSK (0.47) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2155378 | 0.82 | CTSL (0.38) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2156080 | 0.81 | CTSK (0.53) | CTSKCTSSCTSLCTSB | |
| SCHEMBL15855772 | 0.81 | CTSL (0.44) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2155441 | 0.81 | CTSL (0.44) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2155855 | 0.81 | CTSL (0.54) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4954962 | 0.80 | CTSK (0.41) | CTSKCTSSCTSLCTSBEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482924-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2006-03-08 | — | — | EP | disclosed |
| EP-1482924-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075836-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-09-18 | — | — | WO | disclosed |