Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.49 |
| ▸ | CHRNG | P07510 | 2/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | CHRND | Q07001 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746092 | 0.82 | LMNA (0.43) | SLC6A2SLC6A3CYP2C19HRH1KCNH2 | |
| SCHEMBL5746425 | 0.79 | SLC6A2 (0.50) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL28529322 | 0.77 | PARP1 (0.52) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5370186 | 0.75 | GSK3B (0.50) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL8159886 | 0.74 | SLC6A2 (0.63) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL9954465 | 0.74 | SLC6A2 (0.51) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL29589450 | 0.73 | SLC6A2 (0.58) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2070613 | 0.73 | SLC6A2 (0.61) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2599159 | 0.73 | SLC6A2 (0.61) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5256414 | 0.73 | SLC6A2 (0.61) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842923-B1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU CO LTD (JP) | 2006-03-01 | — | — | EP | disclosed |
| CN-1090617-C | Pyrrole derivatives and pharmaceutical compositions | NIPPON SHINYAKU CO LTD (JP) | 2002-09-11 | — | — | CN | disclosed |
| US-6172102-B1 | POLLAKIURIA OR URINARY INCONTINENCE | NIPPON SHINYAKU CO., LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| US-5998459-A | INCOTINENCE THERAPY | NIPPON SHINYAKU CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| CN-1186485-A | Pyrrole derivatives and pharmaceutical compositions | NIPPON SHINYAKU CO LTD (JP) | 1998-07-01 | — | — | CN | disclosed |
| EP-0842923-A1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |