Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | USP10 | Q14694 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574447 | 1.00 | VCAM1 (0.44) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL10224543 | 1.00 | VCAM1 (0.44) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL11517426 | 0.93 | VCAM1 (0.46) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL11510429 | 0.91 | POLB (0.48) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL574048 | 0.91 | TPMT (0.38) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL574046 | 0.91 | TPMT (0.38) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL574029 | 0.91 | VCAM1 (0.46) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL10222900 | 0.91 | VCAM1 (0.46) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL574047 | 0.91 | TPMT (0.38) | VCAM1POLBMAPTHPGDALDH1A1 | |
| SCHEMBL573657 | 0.91 | VCAM1 (0.46) | VCAM1POLBMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |