Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745016 | 0.95 | SLC6A4 (0.61) | HTR1BHTR1DSLC6A4HRH1ADRB2 | |
| SCHEMBL5749472 | 0.89 | MAOA (0.61) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL5748119 | 0.86 | HTR1B (0.55) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL5748148 | 0.85 | HTR1B (0.62) | HTR1BHTR1DSLC6A4HRH1ADRB2 | |
| SCHEMBL5748462 | 0.85 | MAOA (0.59) | HTR1BHTR1DSLC6A4HRH1KDM4E | |
| SCHEMBL5748395 | 0.84 | HTR1B (0.63) | HTR1BHTR1DSLC6A4HRH1ADRB2 | |
| SCHEMBL5749350 | 0.84 | HTR1B (0.57) | HTR1BHTR1DSLC6A4HRH1ADRB2 | |
| SCHEMBL5748338 | 0.83 | HTR1B (0.58) | HTR1BHTR1DSLC6A4HRH1ADRB2 | |
| SCHEMBL15473271 | 0.83 | CYP2A6 (0.59) | HTR1BHTR1DADRB2KDM4ELMNA | |
| SCHEMBL5746754 | 0.82 | HRH1 (0.56) | HTR1BHTR1DSLC6A4HRH1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |