Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | HTR1B | P28222 | 5/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CDC25C | P30307 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748119 | 0.96 | HTR1B (0.55) | HRH1SLC6A4HTR1BHTR1DKDM4E | |
| SCHEMBL5749229 | 0.87 | HTR1B (0.58) | HTR1BHTR1DADRB2KDM4ELMNA | |
| SCHEMBL5745016 | 0.86 | SLC6A4 (0.61) | HRH1SLC6A4HTR1BHTR1DADRB2 | |
| SCHEMBL5748123 | 0.86 | HTR1B (0.59) | HTR1BHTR1DADRB2KDM4ELMNA | |
| SCHEMBL5748462 | 0.84 | MAOA (0.59) | HRH1SLC6A4HTR1BHTR1DCYP3A4 | |
| SCHEMBL5746334 | 0.82 | HTR1B (0.53) | HTR1BCYP1A2CYP2C9L3MBTL1KDM4E | |
| SCHEMBL5744798 | 0.82 | HTR1B (0.60) | HRH1SLC6A4HTR1BHTR1DADRB2 | |
| SCHEMBL5749087 | 0.81 | HTR1B (0.51) | HTR1BTP53CYP1A2CYP2C9L3MBTL1 | |
| SCHEMBL10652572 | 0.80 | CYP2A6 (0.55) | TSHRL3MBTL1KDM4EMAPT | |
| SCHEMBL5749472 | 0.80 | MAOA (0.61) | HRH1SLC6A4HTR1BHTR1DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |