Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 5/20 | 0.49 |
| ▸ | HPGDS | O60760 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860102 | 1.00 | PRKAA2 (0.49) | PRKAA2HPGDSALDH1A1POLBMRGPRX1 | |
| SCHEMBL3866714 | 0.90 | USP30 (0.54) | PRKAA2HPGDSALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3868043 | 0.87 | MAPT (0.48) | HPGDSALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3857038 | 0.85 | POLB (0.50) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5747491 | 0.85 | POLB (0.50) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3862880 | 0.85 | ALDH1A1 (0.53) | HPGDSALDH1A1 | |
| SCHEMBL5746938 | 0.85 | ALDH1A1 (0.53) | HPGDSALDH1A1 | |
| SCHEMBL3860236 | 0.84 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL5747495 | 0.84 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL3861404 | 0.84 | ALDH1A1 (0.55) | HPGDSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | disclosed |