Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857038 | 1.00 | POLB (0.50) | POLBKMT2AKDM4EALOX15ALDH1A1 | |
| SCHEMBL5748950 | 0.87 | MEN1 (0.50) | POLBKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3858172 | 0.87 | MEN1 (0.50) | POLBKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3866714 | 0.87 | USP30 (0.54) | POLBKMT2AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL5745163 | 0.85 | PRKAA2 (0.49) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3860102 | 0.85 | PRKAA2 (0.49) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL5747603 | 0.84 | KDM4E (0.53) | POLBKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3863212 | 0.84 | KDM4E (0.53) | POLBKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5746938 | 0.83 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL3862880 | 0.83 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | claimed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | claimed |