Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745439 | 1.00 | CFTR (0.39) | CFTRHDAC3HDAC2CNR2SMPD1 | |
| SCHEMBL4943701 | 0.87 | EPHX2 (0.39) | CFTRCYP2C9POLB | |
| SCHEMBL4943697 | 0.87 | EPHX2 (0.39) | CFTRCYP2C9POLB | |
| SCHEMBL4941694 | 0.78 | ALDH1A1 (0.37) | CYP2C9L3MBTL1POLBKDM4E | |
| SCHEMBL4941699 | 0.78 | ALDH1A1 (0.37) | CYP2C9L3MBTL1POLBKDM4E | |
| SCHEMBL4942929 | 0.78 | EPHX2 (0.40) | CFTRCYP2C9POLBMAPK1 | |
| SCHEMBL4942950 | 0.71 | EPHX2 (0.39) | CFTRCYP2C9L3MBTL1POLB | |
| SCHEMBL4942949 | 0.71 | EPHX2 (0.39) | CFTRCYP2C9L3MBTL1POLB | |
| SCHEMBL4945246 | 0.70 | EPHX2 (0.38) | CFTRCYP2C9L3MBTL1POLB | |
| SCHEMBL4938441 | 0.66 | MMP1 (0.35) | CFTRCNR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |