⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29953193 | 1.00 | — | — | |
| SCHEMBL27552624 | 0.83 | S1PR4 (0.34) | — | |
| SCHEMBL13117471 | 0.77 | — | — | |
| SCHEMBL29026954 | 0.77 | LOXL2 (0.52) | — | |
| SCHEMBL7609085 | 0.76 | ERN1 (0.38) | — | |
| SCHEMBL986987 | 0.74 | ALDH1A1 (0.38) | — | |
| SCHEMBL12519534 | 0.74 | ALDH1A1 (0.47) | — | |
| SCHEMBL24766044 | 0.73 | — | — | |
| SCHEMBL1094456 | 0.73 | — | — | |
| SCHEMBL5700538 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931044-B1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6- (SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6- (SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2017-07-05 | — | — | EP | claimed |
| US-9433622-B2 | Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-06 | — | — | US | disclosed |
| US-9433622-B2 | Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-06 | — | — | US | disclosed |
| EP-2958910-B1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LTD (GB) | 2016-08-03 | — | — | EP | disclosed |
| US-20160000784-A1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LIMITED (GB) | 2016-01-07 | — | — | US | disclosed |
| US-20160000784-A1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LIMITED (GB) | 2016-01-07 | — | — | US | disclosed |
| WO-2014128486-A1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LIMITED (GB) | 2014-08-28 | — | — | WO | disclosed |
| CN-101172993-A | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections | CENTRE NAT RECH SCIENT (KY) | 2008-05-07 | — | — | CN | disclosed |
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |
| CN-1678326-A | 2 '-C-methyl-3' -O-L-valine ester ribofuranosyl cytidine for treatment of flavivirus infections | IDENIX CAYMAN LTD (KY) | 2005-10-05 | — | — | CN | disclosed |
| CN-1322197-A | Novel 4-amino-1-arylpyridin-2-ones having anticonvulsant activity and process for preparing same | DRESDEN ARZNEIMITTEL (DE) | 2001-11-14 | — | — | CN | disclosed |