Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786122 | 0.87 | GSK3B (0.59) | GSK3BPTPN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL15018952 | 0.86 | GSK3B (0.58) | GSK3BPTPN1MAPTL3MBTL1NPC1 | |
| SCHEMBL1373155 | 0.82 | GSK3B (0.58) | GSK3BPTPN1MAPTL3MBTL1NPC1 | |
| SCHEMBL5055145 | 0.82 | L3MBTL1 (0.65) | GSK3BMAPTL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL11728169 | 0.82 | GSK3B (0.58) | GSK3BPTPN1MAPTL3MBTL1GAA | |
| SCHEMBL5057170 | 0.82 | L3MBTL1 (0.70) | GSK3BPTPN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL2985635 | 0.81 | GSK3B (0.53) | GSK3BPTPN1MAPTL3MBTL1GAA | |
| Bromide SCHEMBL931587 | 0.81 | GSK3B (0.56) | GSK3BPTPN1MAPTL3MBTL1NPC1 | |
| SCHEMBL2953290 | 0.81 | GSK3B (0.66) | GSK3BPTPN1MAPTL3MBTL1THRA | |
| SCHEMBL22007778 | 0.80 | GSK3B (0.51) | GSK3BPTPN1MAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842923-B1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU CO LTD (JP) | 2006-03-01 | — | — | EP | disclosed |
| US-6172102-B1 | POLLAKIURIA OR URINARY INCONTINENCE | NIPPON SHINYAKU CO., LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| US-5998459-A | INCOTINENCE THERAPY | NIPPON SHINYAKU CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0842923-A1 | PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |