Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 5/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866749 | 1.00 | CCNK (0.42) | CCNKCDK12LMNAALDH1A1HRH2 | |
| SCHEMBL5745659 | 0.88 | HRH3 (0.48) | CCNKCDK12LMNAALDH1A1PRKAB2 | |
| SCHEMBL3862507 | 0.88 | HRH3 (0.48) | CCNKCDK12LMNAALDH1A1PRKAB2 | |
| SCHEMBL3862481 | 0.84 | PRKAA2 (0.45) | CCNKCDK12LMNAALDH1A1PRKAB2 | |
| SCHEMBL5749702 | 0.84 | PRKAA2 (0.45) | CCNKCDK12LMNAALDH1A1PRKAB2 | |
| SCHEMBL5750443 | 0.82 | LMNA (0.42) | CCNKCDK12LMNAALDH1A1PIK3CD | |
| SCHEMBL3856209 | 0.82 | LMNA (0.42) | CCNKCDK12LMNAALDH1A1PIK3CD | |
| SCHEMBL3862880 | 0.82 | ALDH1A1 (0.53) | CCNKCDK12LMNAALDH1A1KMT2A | |
| SCHEMBL5746938 | 0.82 | ALDH1A1 (0.53) | CCNKCDK12LMNAALDH1A1KMT2A | |
| SCHEMBL5747117 | 0.81 | PRKAA2 (0.61) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | claimed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | claimed |
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | disclosed |