Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | PARP1 | P09874 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CASP7 | P55210 | 2/20 | 0.65 |
| ▸ | RGS12 | O14924 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.65 |
| ▸ | MTOR | P42345 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11174222 | 0.85 | CDK5 (0.59) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL4341892 | 0.83 | CES1 (0.48) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL4959190 | 0.80 | TYMS (0.61) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL16117999 | 0.79 | KMT2A (0.65) | MEN1KMT2AUSP2POLBCYP1A2 | |
| SCHEMBL13662348 | 0.79 | KEAP1 (0.56) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL5746130 | 0.78 | MEN1 (0.62) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL18590078 | 0.78 | MEN1 (0.62) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL21124 | 0.78 | KMT2A (1.00) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL9968963 | 0.78 | MEN1 (0.62) | MEN1KMT2APARP1USP2NPSR1 | |
| SCHEMBL30517110 | 0.78 | POLB (0.62) | MEN1KMT2APARP1USP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |