Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4841321 | 0.99 | TSPO (0.60) | TSPOALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL4836958 | 0.91 | TSPO (0.61) | TSPOALDH1A1HPGDNPSR1 | |
| SCHEMBL6256479 | 0.85 | TSPO (0.71) | TSPOALDH1A1SMN1; SMN2 | |
| SCHEMBL5746061 | 0.85 | TSPO (0.60) | TSPO | |
| SCHEMBL7493004 | 0.84 | TSPO (0.61) | TSPOALDH1A1SMN1; SMN2HTTTP53 | |
| SCHEMBL5745978 | 0.84 | TSPO (0.84) | TSPO | |
| SCHEMBL3920709 | 0.84 | SMN1; SMN2 (0.50) | TSPOHPGDSMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL4839588 | 0.84 | TSPO (0.59) | TSPO | |
| Hydrochloric Acid SCHEMBL4857420 | 0.83 | TSPO (0.82) | TSPO | |
| SCHEMBL3919188 | 0.83 | SMN1; SMN2 (0.49) | TSPOHPGDSMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492792-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO¬4,5-B|INDOLE-1-ACETAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | EP | disclosed |
| EP-1492792-A2 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO 4,5-B]INDOLE-1-ACETAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN MEDICAMENTS | Sanofi-Aventis (FR) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082874-A2 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-ACETAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN MEDICAMENTS | SANOFI-AVENTIS (FR) | 2003-10-09 | — | — | WO | disclosed |