Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870736 | 0.85 | ALDH1A1 (0.43) | NCF1TLR8ALDH1A1HPGDMAPT | |
| SCHEMBL17474324 | 0.82 | TLR8 (0.47) | TLR8CYP1A2KDM4E | |
| SCHEMBL5747355 | 0.79 | TLR8 (0.48) | TLR8 | |
| SCHEMBL5749855 | 0.79 | TLR8 (0.48) | TLR8 | |
| SCHEMBL5748448 | 0.79 | TLR8 (0.48) | TLR8 | |
| SCHEMBL16720014 | 0.74 | POLB (0.39) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL19359 | 0.72 | CYP1A2 (0.46) | NCF1ALDH1A1HPGDMAPTGLA | |
| SCHEMBL8917079 | 0.72 | MEN1 (0.46) | TLR8ALDH1A1MAPTCYP1A2KDM4E | |
| SCHEMBL21195871 | 0.72 | TLR8 (0.46) | TLR8ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL10628102 | 0.72 | ELANE (0.37) | TLR8ALDH1A1HPGDMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311760-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS | BAYLOR COLLEGE OF MEDICINE | 2016-10-27 | — | — | US | disclosed |
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |
| US-6057318-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER | SANOFI (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5891894-A | 2-AMINO OXAZOLE DERIVATIVES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, INFLAMMATION, CARDIOVASCULAR DISORDERS, RENAL DISEASES, OR AS CONTRACEPTIVES | SANOFI (FR) | 1999-04-06 | — | — | US | disclosed |
| US-5891893-A | 5-AMINO-1,2,4-OXA(OR THIA)DIAZOLES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION, CARDIOVASCULAR DISEASES, RENAL DISEASES, OR AS CONTRACEPTIVES | SANOFI (FR) | 1999-04-06 | — | — | US | disclosed |
| US-5780468-A | ANTAGONIST OF PLATELET ACTIVATING FACTOR | SANOFI (FR) | 1998-07-14 | — | — | US | disclosed |
| CN-1038930-C | Azetidinone derivatives useful in preparation of carbapenem antibiotics | SANKYO CO (JP) | 1998-07-01 | — | — | CN | disclosed |
| EP-0845459-A1 | Azetidinone derivatives useful in the preparation of carbapenem antibiotics | Sankyo Company Limited (JP) | 1998-06-03 | — | — | EP | disclosed |
| US-5719275-A | REACTING SILYL ENOL ETHER WITH AZETIDINONE DERIVATIVE TO FORM INTERMEDIATE FOR PENICILLIN-TYPE ANTIBIOTIC | SANKYO COMPANY, LIMITED (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5681951-A | REACTING PENICILLIN DERIVATIVE HAVING SULFINYL OR SULFONYL GROUP IN 2 POSITION WITH SUBSTITUTED MERCAPTAN IN PRESENCE OF SALT OF GROUP IIA OR IIIA ELEMENT | SANKYO COMPANY, LIMITED (JP) | 1997-10-28 | — | — | US | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5614624-A | THIO SUBSTITUTED, ANTIBIOTICS, CHEMICAL INTERMEDIATES | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5541317-A | PENICILLIN DERIVATIVES, CYCLIZATION OF ESTERS OR THIOESTERS | SANKYO COMPANY, LIMITED (JP) | 1996-07-30 | — | — | US | disclosed |
| US-5470855-A | Anticoagulants | SANOFI (FR) | 1995-11-28 | — | — | US | disclosed |
| CN-1068108-A | Be used to prepare the aza cyclo-butanone derivatives of carbapenem antibiotics | SANKYO CO (JP) | 1993-01-20 | — | — | CN | disclosed |
| EP-0516486-A2 | Azetidinone derivatives useful in the preparation of carbapenem antibiotics | Sankyo Company Limited (JP) | 1992-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311760-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS | RYR2, RYR1, KCNN2 | NCF1 2222/4885TLR8 4806/4885ALDH1A1 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.