Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202545 | 0.93 | PKM (0.47) | PKMF2PRSS1PRSS2PRSS3 | |
| SCHEMBL19243561 | 0.80 | — | — | |
| SCHEMBL13112930 | 0.79 | NPSR1 (0.44) | F2PRSS1PRSS2PRSS3MMP1 | |
| SCHEMBL13112931 | 0.78 | NPSR1 (0.43) | F2PRSS1PRSS2PRSS3MMP1 | |
| SCHEMBL13112933 | 0.78 | MMP1 (0.38) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL13165155 | 0.74 | CA12 (0.39) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL14499654 | 0.74 | MEN1 (0.46) | MEN1KMT2ANPSR1 | |
| SCHEMBL31220617 | 0.74 | MEN1 (0.50) | MEN1KMT2ANPSR1 | |
| SCHEMBL13112923 | 0.73 | MMP1 (0.40) | MMP1MMP2MMP9MMP13 | |
| SCHEMBL13112925 | 0.73 | CA1 (0.56) | PKMF2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |