Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23948514 | 0.93 | PDE4B (0.48) | PDE4BMAPK8MAPK9SYKMERTK | |
| SCHEMBL15249748 | 0.86 | SYK (0.51) | PDE4BSYKMERTKPPARGMEN1 | |
| SCHEMBL5744856 | 0.85 | ALDH1A1 (0.55) | PDE4BMAPK8MAPK9SYKMEN1 | |
| SCHEMBL5744853 | 0.85 | ALDH1A1 (0.55) | PDE4BMAPK8MAPK9SYKMEN1 | |
| SCHEMBL23948144 | 0.84 | IRAK4 (0.38) | PDE4BSYKTYRO3MEN1KMT2A | |
| SCHEMBL1226594 | 0.84 | MEN1 (0.49) | MAPK8SYKMERTKPPARGMEN1 | |
| SCHEMBL26161013 | 0.84 | SYK (0.49) | MAPK8SYKMERTKPPARGMEN1 | |
| SCHEMBL26931042 | 0.81 | MERTK (0.57) | MAPK8MAPK9SYKMERTKTYRO3 | |
| SCHEMBL26931049 | 0.81 | MERTK (0.57) | MAPK8MAPK9SYKMERTKTYRO3 | |
| SCHEMBL21591892 | 0.81 | MAPK8 (0.43) | MAPK8MAPK9MERTKTYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615928-A1 | PYRIMIDO COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-01-18 | — | — | EP | claimed |
| WO-2004089955-A1 | PYRIMIDO COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-10-21 | — | — | WO | claimed |