Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | AOC2 | O75106 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28367193 | 0.81 | TAAR1 (0.54) | TAAR1ELOVL1MAOBIDO1AGXT | |
| SCHEMBL5347405 | 0.81 | ESR1 (0.48) | TAAR1SMN1; SMN2IDO1 | |
| SCHEMBL10056649 | 0.81 | PPARA (0.35) | — | |
| SCHEMBL13370306 | 0.81 | GFER (0.48) | MAOBMAOALOXL2 | |
| SCHEMBL1978687 | 0.81 | TAAR1 (0.42) | TAAR1MAOBIDO1MAOA | |
| SCHEMBL27901978 | 0.80 | IDO1 (0.48) | SMN1; SMN2MAOBIDO1AGXTMAOA | |
| SCHEMBL144596 | 0.80 | MAPT (0.42) | TAAR1SMN1; SMN2IDO1LOXL2 | |
| SCHEMBL2258380 | 0.79 | TAAR1 (0.49) | TAAR1MAOBIDO1AGXT | |
| SCHEMBL11125764 | 0.78 | FFAR1 (0.42) | TAAR1IDO1AGXT | |
| SCHEMBL5978162 | 0.78 | TAAR1 (0.46) | TAAR1ELOVL1MAOBIDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600853-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016879-A1 | COMBINATIONS COMPRISING ATYPICAL ANTIPSYCHOTICS AND TAAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-09 | — | — | WO | disclosed |
| EP-0649418-B1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | ASTRA PHARMA PROD (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5763465-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-06-09 | — | — | US | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |
| EP-0649418-A1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | Astra Pharmaceuticals Limited (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993024473-A1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | FISONS PLC (GB) | 1993-12-09 | — | — | WO | disclosed |