SCHEMBL57487

SCHEMBL57487

N[C@@H](CO)c1ccc(F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.43
TDO2 P48775 2/20 0.43
AOC3 Q16853 2/20 0.42
TRPA1 O75762 1/20 0.41
DPP4 P27487 2/20 0.41
GABBR2 O75899 1/20 0.40
GABBR1 Q9UBS5 1/20 0.40
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.37
DPP8 Q6V1X1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57488 1.00 IDO1 (0.43) IDO1TDO2AOC3TRPA1DPP4
SCHEMBL3855923 1.00 IDO1 (0.43) IDO1TDO2AOC3TRPA1DPP4
Hydrochloric Acid SCHEMBL1439116 0.98 IDO1 (0.45) IDO1TDO2AOC3TRPA1DPP4
Hydrochloric Acid SCHEMBL1439114 0.98 IDO1 (0.45) IDO1TDO2AOC3TRPA1DPP4
Formic Acid SCHEMBL27883524 0.90 GABBR2 (0.39) IDO1TDO2AOC3TRPA1DPP4
SCHEMBL1444985 0.87 ANPEP (0.41)
Trifluoroacetic Acid SCHEMBL9299736 0.85 DPP4 (0.47) DPP4DPP8
SCHEMBL971562 0.82 IDO1 (0.40) IDO1TDO2AOC3TRPA1DPP4
SCHEMBL3338459 0.82 IDO1 (0.40) IDO1TDO2AOC3TRPA1DPP4
SCHEMBL30059303 0.82 IDO1 (0.40) IDO1TDO2AOC3TRPA1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206751-A1 HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN ASTELLAS PHARMA INC. (JP) 2025-06-26 US disclosed
EP-4491624-A1 HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN Astellas Pharma Inc. (JP) 2025-01-15 EP disclosed
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US disclosed
WO-2024034657-A1 PHARMACEUTICAL COMPOSITION COMPRISING HETEROCYCLIC COMPOUND アステラス製薬株式会社 2024-02-15 WO disclosed
WO-2024034123-A1 PHARMACEUTICAL COMPOSITION CONTAINING HETEROCYCLIC COMPOUND アステラス製薬株式会社 2024-02-15 WO disclosed
EP-4288412-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP disclosed
CN-116829726-A Biological production of enantiomerically pure (R) -and (S) -2-phenylglycinol from styrene and renewable raw materials by artificial enzyme cascade 新加坡国立大学 2023-09-29 CN disclosed
WO-2023171781-A1 HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN アステラス製薬株式会社 2023-09-14 WO disclosed
WO-2022167866-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2022-08-11 WO disclosed
WO-2021071843-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS Pipeline Therapeutics, Inc. (US) 2021-04-15 WO disclosed
US-5952369-A ANALGESIC, TREATMENT FOR STROKE OR ABDOMINAL PAIN ASSOCIATED WITH FUNCTIONAL BOWEL DISEASE PFIZER INC (US) 1999-09-14 US disclosed
US-5854268-A Azetidine, pyrrolidine and piperidine derivatives MERCK SHARP & DOHME, LTD. (GB) 1998-12-29 US disclosed
US-5814648-A N-hydroxyureas as antiinflammatory agents PFIZER INC. (US) 1998-09-29 US disclosed
EP-0861244-A1 AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1998-09-02 EP disclosed
CN-1191531-A N-hydroxyureas as antiinflammatory agents PFIZER (US) 1998-08-26 CN disclosed
CN-1180348-A Pyrrolidinyl hydroxamic acid compounds and their production process PFIZER (US) 1998-04-29 CN disclosed
EP-0804434-A1 AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1997-11-05 EP disclosed
WO-1997018201-A1 AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1997-05-22 WO disclosed
WO-1996030339-A1 PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS PFIZER INC. (US) 1996-10-03 WO disclosed
WO-1996004274-A1 AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1996-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206751-A1 HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN KRAS, NRAS, HRAS IDO1 3123/4885TDO2 4327/4885AOC3 3231/4885
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPM1A, PPP2CA, PPP3CA IDO1 1178/4885TDO2 3246/4885AOC3 3025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.